Proliferating cell nuclear antigen - Wikipedia
Ctf18-RFC, which consists of the chromosome cohesion factors Ctf18, Dcc1, and Ctf8 and four small RFC subunits, functions as a second proliferating cell nuclear antigen (PCNA) loader.
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A proteomics approach to identify proliferating cell
Aug 08, 2002 · A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity. Shiomi Y, Masutani C, Hanaoka F, Kimura H, Tsurimoto T. J Biol Chem, 282(29):20906-20914, 31 May 2007 Cited by: 18 articles | …
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Structure of the human clamp loader reveals an
GALE A. MCCARTY, in Autoantibodies (Second Edition), 2007. Definition. Proliferating cell nuclear antigen is encoded by a single gene, is approximately 634 base pairs in size, has a molecular weight of 36 kDa, and in
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Proliferation and differentiation of periodontal ligament
The untreated contralateral sides served as the control. Paraffin-embedded sections were analysed by immunohistochemistry for proliferating cell nuclear antigen (PCNA), runt-related transcription factor 2 (Runx2/Cbfa1), and phosphorylated extracellular …
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Proliferating cell nuclear antigen (PCNA): a dancer with
Aug 01, 2003 · Proliferating cell nuclear antigen (PCNA) was originally characterised as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the eukaryotic chromosomal DNA replisome. Alternative clamp loader in sister chromatin cohesion Second pathway for completion of human DNA base excision-repair: reconstitution
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Proliferating cell nuclear antigen - Wikipedia
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics.
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A Second Proliferating Cell Nuclear Antigen Loader Complex
Proliferating cell nuclear antigen - Wikipedia
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Proliferating Cell Nuclear Antigen and in Lung Carcinoma
the proliferation rate of tumor cells using basic and clin- ical techniques. Proliferating cell nuclear antigen (PCNA/cyclin) is a 36-kilodalton, nuclear polypeptide that is related to cell proliferation. The existence of this protein was first indicated when serum from patients with systemic lupus erythematosus reacted with nuclei
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Proliferating cell nuclear antigen (PCNA): a key factor in
Dec 17, 2010 · Ruike T, Takeuchi R, Takata K, et al. Characterization of a second proliferating cell nuclear antigen (PCNA2) from Drosophila melanogaster. The FEBS Journal. 2006; 273:5062–5073. [Google Scholar] Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.
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A second proliferating cell nuclear antigen loader complex
May 31, 2007 · A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity. Yasushi Shiomi Department of Biology, School of Sciences, Kyushu University, Kefid Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
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(PDF) A Second Proliferating Cell Nuclear Antigen Loader
Proliferating Cell Nuclear Antigen - an overview
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The reconstituted human Chl12-RFC complex functions as a
Jul 20, 2007 · Replication factor C (RFC) loads the clamp protein PCNA onto DNA structures. Ctf18-RFC, which consists of the chromosome cohesion factors Ctf18, Dcc1,…
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Mark Hedglin — Penn State
Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch Gaubitz, C., Liu, X., Proliferating Cell Nuclear Antigen 70%. Antigen 54%. Protein 26%. DNA 18%. 13 Scopus citations. View all 18 Research outputs
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A Second Proliferating Cell Nuclear Antigen Loader Complex
Proliferating cell nuclear antigen - Wikipedia
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Proliferating Cell Nuclear Antigen - an overview
Ctf18-RFC, which consists of the chromosome cohesion factors Ctf18, Dcc1, and Ctf8 and four small RFC subunits, functions as a second proliferating cell nuclear antigen (PCNA) loader. To identify potential targets of Ctf18-RFC, human cell extracts were assayed for DNA polymerase activity specifically stimulated by Ctf18-RFC in conjunction with PCNA.
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Stable Interaction between the Human Proliferating Cell
Nov 05, 2010 · Introduction. The eukaryotic loader complex replication factor C (RFC) 2 consists of one large and four small subunits (RFC1 and RFC2–5, respectively) and loads the clamp complex proliferating cell nuclear antigen (PCNA) onto a primer/template DNA through its ATPase activity. PCNA is a homotrimeric complex functioning as the processivity factor for …
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The RFC Clamp Loader: Structure and Function
of the E. coli clamp and the eukaryotic PCNA (proliferating cell nuclear antigen) clamp are shown in Fig. 14.1a (Gulbis et al. 1996 ; Krishna et al. 1994 ) . The eukary otic PCNA clamp is a homotrimer, while the bacterial clamp is a homodimer. Despite . …
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63922 - Gene ResultCHTF18 chromosome transmission fidelity
Nov 25, 2021 · This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase …
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The reconstituted human Chl12‐RFC complex functions as a
1. Genes Cells. 2004 Apr;9(4):279-90. The reconstituted human Chl12-RFC complex functions as a second PCNA loader. Shiomi Y(1), Shinozaki A, Sugimoto K, Usukura J, Obuse C, Tsurimoto T. Author information: (1)Department of Biology, School of Sciences, Kyushu University, Kefid Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
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A Central Swivel Point in the RFC Clamp Loader Controls
The eukaryotic clamp loader replication factor C (RFC) loads proliferating cell nuclear antigen (PCNA) clamps onto DNA, where they serve as processivity factors for replicative polymerases and modulate the functions of many other proteins that work on DNA.1,2 The structure and function of clamp and clamp loader proteins are highly con-
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